The 4th industrial revolution and digitalisation opens new perspectives and provides various challenges for small and medium sized enterprises (SMEs) in internationalisation. The joint event of the UpGradeSME project and the Priority Area 8 of the EU Strategy of the Danube Region (EUSDR) aims at tackling classical and recent challenges and possibilities of internationalization processes. The event will give SMEs from Europe's core regions as well as from the Danube region the opportunity to exchange experiences on internationalisation strategies and address their challenges directly to the representatives from politics and administration present.